Isopropylamine → HCID 70387113, compound

HRID 2292090Notes

Reaction equation

HRID 2292090 reaction equation
[CH3:1][CH:2]1[C:15]2[C:14]3[CH:13]=[CH:12][CH:11]=[N:10][C:9]=3[N:8](Br)[CH2:7][C:6]=2[CH2:5][C:4](=[O:17])[NH:3]1.[CH:18]([NH2:21])([CH3:20])[CH3:19]>C(O)C>[CH3:1][CH:2]1[C:15]2[C:14]3[CH:13]=[CH:12][CH:11]=[N:10][C:9]=3[N:8]([NH:21][CH:18]([CH3:20])[CH3:19])[CH2:7][C:6]=2[CH2:5][C:4](=[O:17])[NH:3]1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 21276722HCID 21276722, compound

Product 1

HCID 70387113HCID 70387113, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.6 g (0.012 mol) of 1-methyl-6-bromo-1,2-dihydropyrido[4,3-c][1,8]naphthyridin-3(4H)-one, 30 ml of absolute ethanol and 10 ml of isopropylamine are stirred for 6 hours at 160° C. in an autoclave. After cooling, the crystalline precipitate is filtered off under suction and recrystallized from methanol. 2.82 g (87% of theory) of 1-methyl-6-isopropylamino-1,2-dihydropyrido-[4,3-c][1,8]naphthyridin-3(4H)-one are obtained.

Workup

  1. temperatureAfter cooling
  2. filtrationthe crystalline precipitate is filtered off under suction
  3. customrecrystallized from methanol

Sources & evidence

ORD record
ord-61584b3b483749068a377de30d126c26
Source dataset
uspto-grants-1989_01
Patent number
US04801590

Reaction notes

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