HCID 21276841, compound → HCID 20086457, compound

2-(4-Chloro-6-hydroxymethylphenyl)ethanol (45 g) was dissolved in orthophosphoric acid (200 ml) and the solution was heated at 100° for 2 hr. The cooled reaction mixture was diluted with water (1 liter), extracted with ether (4×200 ml) and the combined ether extract was washed with sodium hydrogen carbonate solution (10% w/v 2×200 ml) and water (200 ml) and then dried (magnesium sulphate) and decolourised with activated carbon and evaporated in vacuo to afford 7-chloroisochroman as an oil, (30 g), characterised by its nmr spectrum.

1. temperaturethe solution was heated at 100° for 2 hr
2. customThe cooled reaction mixture
3. extractionextracted with ether (4×200 ml)
4. extractionthe combined ether extract
5. washwas washed with sodium hydrogen carbonate solution (10% w/v 2×200 ml) and water (200 ml)
6. dry with materialdried (magnesium sulphate)
7. customevaporated in vacuo

ORD record

ord-1b33f4bb1729448d8167fd0b2f6a7c7d

Source dataset

uspto-grants-1989_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04801593