HCID 21276841, compound → HCID 20086457, compound

Participants

Reaction Steps

2-(4-Chloro-6-hydroxymethylphenyl)ethanol (45 g) was dissolved in orthophosphoric acid (200 ml) and the solution was heated at 100° for 2 hr. The cooled reaction mixture was diluted with water (1 liter), extracted with ether (4×200 ml) and the combined ether extract was washed with sodium hydrogen carbonate solution (10% w/v 2×200 ml) and water (200 ml) and then dried (magnesium sulphate) and decolourised with activated carbon and evaporated in vacuo to afford 7-chloroisochroman as an oil, (30 g), characterised by its nmr spectrum.

Provenance & Evidence