Succinamide → 1-(2-Bromoethyl)pyrrolidine-2,5-dione

HRID 2292130Notes

Reaction equation

HRID 2292130 reaction equation
[C:1]([NH2:8])(=[O:7])[CH2:2][CH2:3][C:4](N)=[O:5].[Br:9][CH:10](Br)[CH3:11].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:9][CH2:10][CH2:11][N:8]1[C:1](=[O:7])[CH2:2][CH2:3][C:4]1=[O:5]

Participants

5

Reactant 3

HCID 8036SuccinamideHCID 112011,1-DibromoethaneHCID 11430Potassium Carbonate

Product 1

HCID 135613951-(2-Bromoethyl)pyrrolidine-2,5-dione

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

49.5 g of succinamide was dissolved in 750 ml of 2-butanone under heating. 187.9 g of dibromoethane and 138 g of anhydrous potassium carbonate were added to the solution and the mixture was heated under reflux for 9.5 h.

Workup

  1. temperatureunder heating
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 9.5 h.

Sources & evidence

ORD record
ord-c828f9b75a7a408abe6987fc6ce65114
Source dataset
uspto-grants-1989_01
Patent number
US04801603

Reaction notes

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