反应详情

3.4 g of 2-ethoxyethyl 4-hydroxyphenyl sulfide was dissolved in 50 ml of pyridine. 4-Guanidinobenzoyl chloride was added to the solution under cooling with ice and the mixture was stirred at room temperature for 27 h. A saturated aqueous solution of sodium hydrocarbonate was added thereto under cooling with ice. A precipitate thus formed was recovered by filtration, washed with water and then with acetone, and dried to obtain 2.86 g (yield: 40%) of 4-(2-ethoxyethylthio)phenyl 4-guanidinobenzoate carbonate.

1. temperatureunder cooling with ice
2. temperatureunder cooling with ice
3. customA precipitate thus formed
4. filtrationwas recovered by filtration
5. washwashed with water
6. dry with materialwith acetone, and dried