反应详情

The hydrochloride salt of this cis-N-[2-(dimethylamino)cyclohexyl]benzamide was made by dissolving this amino-amide compound in excess hydrogen chloride in ether solution and then evaporating solvent therefrom to crystallize the hydrochloride salt therefrom. This amino-amide hydrochloride salt was recrystallized from a mixture of 10 ml. of methanol an about 40 ml. of ether to obtain 2.13 g. (75 percent yield) of the cis-N-[2-(dimethylamino)cyclohexyl]benzamide hydrochloride, m.p. 247°-248° C.

1. customevaporating solvent therefrom to crystallize the hydrochloride salt
2. customThis amino-amide hydrochloride salt was recrystallized from a mixture of 10 ml
3. customof ether to obtain 2.13 g