2-Chlorobenzaldehyde → HCID 21276954, compound

HRID 2292139Notes

Reaction equation

HRID 2292139 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:11][CH2:12][CH2:13][O:14][CH2:15][C:16](=O)[CH2:17][C:18]([O:20][CH:21]([CH3:23])[CH3:22])=[O:19].[Cl:25][C:26]1[CH:33]=[CH:32][CH:31]=[CH:30][C:27]=1[CH:28]=O.[C:34]([NH:38][C:39](=[O:44])/[CH:40]=[C:41](\[NH2:43])/[CH3:42])([CH3:37])([CH3:36])[CH3:35]>>[C:34]([NH:38][C:39]([C:40]1[CH:28]([C:27]2[CH:30]=[CH:31][CH:32]=[CH:33][C:26]=2[Cl:25])[C:17]([C:18]([O:20][CH:21]([CH3:23])[CH3:22])=[O:19])=[C:16]([CH2:15][O:14][CH2:13][CH2:12][CH2:11][C:3]2[N:2]([CH3:1])[C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[N:4]=2)[NH:43][C:41]=1[CH3:42])=[O:44])([CH3:37])([CH3:36])[CH3:35]

Participants

4

Reactant 3

HCID 69962-ChlorobenzaldehydeHCID 19864533HCID 19864533, compoundHCID 21276956HCID 21276956, compound

Product 1

HCID 21276954HCID 21276954, compound

Procedure

The procedure of Example 21(c) was followed using isopropyl 4-[3-(1-methylbenzimidazol-2-yl)propoxy]-3-ketobutanoate, 2-chlorobenzaldehyde and N-t-butyl-3-aminocrotonamide as starting materials to yield the title compound as a white solid m.p. 216° C. Found: C, 66.62; H, 6.78; N, 9.35. C33H41ClN4O4 requires C, 66.82; H, 6.97; N, 9.45%.

Sources & evidence

ORD record
ord-926a728666dd4aa68ae14b17cf566c1e
Source dataset
uspto-grants-1989_01
Patent number
US04801598

Reaction notes

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