Nitric Acid → 4'-Fluoro-3'-nitroacetophenone

HRID 2292258Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[N+:11]([O-])([OH:13])=[O:12]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]

Participants

Reactant 2

HCID 944Nitric Acid

HCID 98284'-Fluoroacetophenone

Product 1

HCID 27346124'-Fluoro-3'-nitroacetophenone

Procedure

1-fluoro-4-acetyl-benzene was reacted with nitric acid to obtain 2-fluoro-5-acetyl-nitro benzene with a melting point of 56°-58° C. which was reacted as in Example 1 to obtain 0-(4-acetyl-2-nitro-phenyl)-hydroxylamine melting at 132° C.

Sources & evidence

ORD record: ord-a16b1f1e22e545488e8422425ef21c43
Source dataset: uspto-grants-1989_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04801717

Reaction notes

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