Hydrochloric Acid → HCID 14390899, compound

Participants

Reaction Steps

To a suspension of 12.13 g (34.7 mmol) of 3,4-bis(acetyloxy)-N-(2,3-dioxo-1-piperazinyl)benzamide in 290 ml of methanol and 80 ml of water was added 29 ml of 25N potassium hydroxide solution (72.9 mmol), and the mixture was stirred for 1 hour at room temperature. The pH of the solution was brought to 6.9 with dilute hydrochloric acid, the solution was then concentrated to 100 ml and the precipitate filtered off, washed with water and dried in vacuo (60°-70° C.); yield: 7.85 g, melting point 294° C.

Provenance & Evidence