Hydrochloric Acid → HCID 14390899, compound

HRID 2292337Notes

Reaction equation

HRID 2292337 reaction equation
C([O:4][C:5]1[CH:6]=[C:7]([CH:19]=[CH:20][C:21]=1[O:22]C(=O)C)[C:8]([NH:10][N:11]1[CH2:16][CH2:15][NH:14][C:13](=[O:17])[C:12]1=[O:18])=[O:9])(=O)C.[OH-].[K+].Cl>CO.O>[OH:4][C:5]1[CH:6]=[C:7]([C:8]([NH:10][N:11]2[CH2:16][CH2:15][NH:14][C:13](=[O:17])[C:12]2=[O:18])=[O:9])[CH:19]=[CH:20][C:21]=1[OH:22]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 21277187HCID 21277187, compound

Product 1

HCID 14390899HCID 14390899, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a suspension of 12.13 g (34.7 mmol) of 3,4-bis(acetyloxy)-N-(2,3-dioxo-1-piperazinyl)benzamide in 290 ml of methanol and 80 ml of water was added 29 ml of 25N potassium hydroxide solution (72.9 mmol), and the mixture was stirred for 1 hour at room temperature. The pH of the solution was brought to 6.9 with dilute hydrochloric acid, the solution was then concentrated to 100 ml and the precipitate filtered off, washed with water and dried in vacuo (60°-70° C.); yield: 7.85 g, melting point 294° C.

Workup

  1. concentrationthe solution was then concentrated to 100 ml
  2. filtrationthe precipitate filtered off
  3. washwashed with water
  4. customdried in vacuo (60°-70° C.)

Sources & evidence

ORD record
ord-2d2e9a6633bf4a8c900ede5b3b3e928f
Source dataset
uspto-grants-1989_01
Patent number
US04801705

Reaction notes

Loading…