Hydrochloric Acid → HCID 131715837, compound

HRID 2292345Notes

Reaction equation

HRID 2292345 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([NH:12][NH:13]C(OCC2C=CC=CC=2)=O)=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8].CO.[ClH:26].CCOCC>[Pd]>[ClH:26].[OH:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([NH:12][NH2:13])=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3283Diethyl EtherHCID 14390900HCID 14390900, compound

Product 1

HCID 131715837HCID 131715837, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A solution of 5.03 g (15.85 mmol) of 2-[[(3,4-dihydroxyphenyl)amino]carbonyl]hydrazinecarboxylic acid, phenylmethyl ester in 250 ml of methanol containing 2.64 ml (31.70 mmol) of hydrochloric acid was hydrogenated in the presence of 0.5 g of 10% palladium on charcoal for 5 minutes. The catalyst was filtered off and the solvent was distilled off in vacuo to leave a solid which was stirred with a few ml of dry ether; yield after drying in vacuo: 3.36 g; melting point 170°-180° C., dec.

Workup

  1. filtrationThe catalyst was filtered off
  2. distillationthe solvent was distilled off in vacuo
  3. customto leave a solid which
  4. customyield
  5. customafter drying in vacuo

Sources & evidence

ORD record
ord-12f749886d4949aeb9357a22ca8cc3ca
Source dataset
uspto-grants-1989_01
Patent number
US04801705

Reaction notes

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