Hydrochloric Acid → HCID 131715838, compound

HRID 2292349Notes

Reaction equation

HRID 2292349 reaction equation
C1(COC([NH:11][NH:12][C:13]([NH:15][NH:16][C:17](=[O:26])[C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([OH:25])[CH:19]=2)=[O:14])=O)C=CC=CC=1.CO.[ClH:29].CCOCC>[Pd]>[ClH:29].[NH:12]([C:13]([NH:15][NH:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([OH:25])[CH:19]=1)=[O:14])[NH2:11]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3283Diethyl EtherHCID 56974509HCID 56974509, compound

Product 1

HCID 131715838HCID 131715838, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A solution of 3.60 g (10.0 mmol) of 3,4-dihydroxybenzoic acid, 2-[[2-[(phenylmethoxy)carbonyl]hydrazino]carbonyl]hydrazide in 90 ml of dry methanol containing 1.67 ml (20.0 mmol) of concentrated hydrochloric acid was hydrogenated in the presence of 0.36 g of 10% palladium on charcoal for 15 minutes. After the removal of the catalyst by filtration and of the solvent by evaporation in vacuo, the crude solid (2.61 g) was stirred with a few ml of dry ether; yield: 2.41 g.

Workup

  1. customAfter the removal of the catalyst
  2. filtrationby filtration
  3. customof the solvent by evaporation in vacuo

Sources & evidence

ORD record
ord-cf243f62aca54232b81da82531484132
Source dataset
uspto-grants-1989_01
Patent number
US04801705

Reaction notes

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