Potassium Hydroxide → HCID 14390904, compound

HRID 2292368Notes

Reaction equation

HRID 2292368 reaction equation
Cl[CH2:2][CH2:3][NH:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=1)=[O:6].[OH-].[K+]>C(O)C>[CH3:17][O:16][C:10]1[CH:9]=[C:8]([N:7]2[CH2:2][CH2:3][NH:4][C:5]2=[O:6])[CH:13]=[CH:12][C:11]=1[O:14][CH3:15]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 14390903HCID 14390903, compound

Product 1

HCID 14390904HCID 14390904, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 82.6 g (0.32 mol) of 1-chloro-2-[[[(3,4-dimethoxyphenyl)amino]carbonyl]amino]ethane in 800 ml of ethanol was added dropwise a solution of 21.5 g (0.383 mol) of potassium hydroxide in 400 ml of ethanol. The mixture was stirred for two days at room temperature and the precipitate filtered off by suction. The crude product was recrystallized from 1.5 l of ethyl acetate containing 10% methanol; yield, 52.5 g; melting point 168° C.

Workup

  1. filtrationthe precipitate filtered off by suction
  2. customThe crude product was recrystallized from 1.5 l of ethyl acetate containing 10% methanol
  3. customyield

Sources & evidence

ORD record
ord-608f24b573c04deb8b11b8b32b8481bd
Source dataset
uspto-grants-1989_01
Patent number
US04801705

Reaction notes

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