Potassium Hydroxide → HCID 14390904, compound

Participants

Reaction Steps

To a solution of 82.6 g (0.32 mol) of 1-chloro-2-[[[(3,4-dimethoxyphenyl)amino]carbonyl]amino]ethane in 800 ml of ethanol was added dropwise a solution of 21.5 g (0.383 mol) of potassium hydroxide in 400 ml of ethanol. The mixture was stirred for two days at room temperature and the precipitate filtered off by suction. The crude product was recrystallized from 1.5 l of ethyl acetate containing 10% methanol; yield, 52.5 g; melting point 168° C.

Provenance & Evidence