Water → HCID 21277164, compound

HRID 2292369Notes

Reaction equation

HRID 2292369 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:15][CH2:14][NH:13][C:12]2=[O:16])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].ClS([N:21]=[C:22]=[O:23])(=O)=O.O>C(OCC)(=O)C>[NH2:21][C:22]([N:13]1[CH2:14][CH2:15][N:11]([C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)[C:12]1=[O:16])=[O:23]

Participants

5

Reactant 3

HCID 962WaterHCID 70918Chlorosulfonyl isocyanateHCID 14390904HCID 14390904, compound

Product 1

HCID 21277164HCID 21277164, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 13.33 g (60 mmol) of 1-(3,4-dimethoxyphenyl)-2-imidazolidinone in 150 ml of ethyl acetate was cooled to 0° C., and 8.92 g (63 mmol) of chlorosulfonylisocyanate was added dropwise. The mixture was stirred for one hour at room temperature. To the resulting thick suspension was added 50 ml of water, and the mixture was stirred until two clear layers were formed. The aqueous phase was separated and stored in the refrigerator overnight. The precipitate was filtered off by suction, washed with water and dried in vacuo; yield: 11.04 g; melting point 240° C.

Workup

  1. stirringthe mixture was stirred until two clear layers
  2. customwere formed
  3. customThe aqueous phase was separated
  4. customstored in the refrigerator overnight
  5. filtrationThe precipitate was filtered off by suction
  6. washwashed with water
  7. customdried in vacuo

Sources & evidence

ORD record
ord-e6bfae29d814466b9e38d8d1958b6200
Source dataset
uspto-grants-1989_01
Patent number
US04801705

Reaction notes

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