Octanal → 1-(2,3-Difluorophenyl)octan-1-ol

HRID 2292410Notes

Reaction equation

C([Li])CCC.[CH:6](=[O:14])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[F:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[F:22]>>[F:15][C:16]1[C:17]([F:22])=[CH:18][CH:19]=[CH:20][C:21]=1[CH:6]([OH:14])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

Reactant 3

HCID 454Octanal

HCID 97061,2-Difluorobenzene

HCID 178418339Butyllithium

Product 1

HCID 536998501-(2,3-Difluorophenyl)octan-1-ol

Procedure

Quantities: n-butyllithium (30 cm3, 10.0M in hexanes, 0.3 mol), octanal (38.5 g, 0.3 mol) and 1,2-difluorobenzene (34.5 g, 0.3 mol). The experimental procedure was as described in Example 16.

Sources & evidence

ORD record: ord-ba343085dc66437aa2ca2448d3ca987c
Source dataset: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05683623

Reaction notes

Loading…