1,2-Difluorobenzene → HCID 21477972, compound

HRID 2292411Notes

Reaction equation

C([Li])CCC.[CH:6](=[O:15])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[F:23]>>[F:16][C:17]1[C:18]([F:23])=[CH:19][CH:20]=[CH:21][C:22]=1[CH:6]([OH:15])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

Reactant 3

HCID 97061,2-Difluorobenzene

HCID 31289Nonanal

HCID 178418339Butyllithium

Product 1

HCID 21477972HCID 21477972, compound

Procedure

Quantities: n-butyllithium (50 cm3, 10.0M in hexanes, 0.5 mol), nonanal (71 g, 0.5 mol) and 1,2-difluorobenzene (57 g, 0.5 mol). The experimental procedure was as described in Example 16.

Sources & evidence

ORD record: ord-357c996d080b46e588166d1015a65948
Source dataset: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05683623

Reaction notes

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