Decanal → (2,3-Difluorophenyl)decan-1-ol

HRID 2292412Notes

Reaction equation

C([Li])CCC.[CH:6](=[O:16])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[F:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[F:24]>>[F:17][C:18]1[C:19]([F:24])=[CH:20][CH:21]=[CH:22][C:23]=1[CH:6]([OH:16])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

Participants

Reactant 3

HCID 8175Decanal

HCID 97061,2-Difluorobenzene

HCID 178418339Butyllithium

Product 1

HCID 21477954(2,3-Difluorophenyl)decan-1-ol

Procedure

Quantities: n-butyllithium (30 cm3, 10.0M in hexanes, 0.3 mol), decanal (47 g, 0.3 mol) and 1,2-difluorobenzene (34.5 g, 0.3 mol). The experimental procedure was as described in Example 16.

Sources & evidence

ORD record: ord-c577ab599b5c4de792021d00d88ac94f
Source dataset: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05683623

Reaction notes

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