Methyl morpholine oxide → HCID 54571409, compound

HRID 2292493Notes

Reaction equation

HRID 2292493 reaction equation
F[C:2](F)([F:29])[CH2:3][CH2:4][CH2:5][CH:6]([C@H:8]1[CH2:13][CH2:12][C@H:11]2[C@H:14]3[C@H:24]([CH2:25][CH2:26][C@:9]12[CH3:10])[C@:22]1([CH3:23])[C:17]([CH:18]=[C:19]([CH2:27][OH:28])[CH2:20][CH2:21]1)=[CH:16][CH2:15]3)[OH:7].C[N+]1([O-])CCO[CH2:34][CH2:33]1>C(Cl)Cl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[F:29][C:2]1[CH:34]=[CH:33][C:5]([C:6]([C@H:8]2[CH2:13][CH2:12][C@H:26]3[C@H:25]4[C@H:24]([CH2:14][CH2:11][C@:9]23[CH3:10])[C@:22]2([CH3:23])[C:17]([CH:18]=[C:19]([CH:27]=[O:28])[CH2:20][CH2:21]2)=[CH:16][CH2:15]4)=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 82029Methyl morpholine oxideHCID 53978241HCID 53978241, compound

Product 1

HCID 54571409HCID 54571409, compound

Reagents, catalysts & solvents 2

HCID 178419074HCID 178419074, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Tetrapropyl ammonium perruthenate is added to a solution of (17β)-17-(5,5,5-trifluoro-1-hydroxypentyl)-androsta-3,5-diene-3-methanol and 4-methylmorpholine N-oxide in CH2Cl2 (2.0 ml) at RT. After 1 h the reaction is flash chromatographed to yield the title compound.

Workup

  1. customflash chromatographed

Sources & evidence

ORD record
ord-90134d5f1d39408aa5d31dbbbce95c47
Source dataset
uspto-grants-1997_11
Patent number
US05683995

Reaction notes

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