4-Oxo-4H-1-benzopyran-2-carbonyl chloride → HCID 12752076, compound

HRID 2292627Notes

Reaction equation

HRID 2292627 reaction equation
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH:3]=[C:2]1[C:12](Cl)=[O:13].[Cl-].[Al+3].[Cl-].[Cl-]>C1(OC)C=CC=CC=1>[CH3:2][O:1][C:10]1[CH:5]=[CH:6][C:7]([C:12]([C:2]2[O:1][C:10]3[C:5]([C:4](=[O:11])[CH:3]=2)=[CH:6][CH:7]=[CH:8][CH:9]=3)=[O:13])=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 787884-Oxo-4H-1-benzopyran-2-carbonyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 12752076HCID 12752076, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Procedure

Combine chromone-2-carboxylic acid chloride (10 mmol), and aluminum chloride (30 mmol) in anisole (70 mL). Heat at reflux for 24 hours. Pour the reaction mixture into ice-water (150 mL). Extract twice with dichloromethane. Dry the separated organic layers over MgSO4, filter, and evaporate in vacuo. Chromatograph on silica gel to give the title compound.

Workup

  1. temperatureHeat
  2. temperatureat reflux for 24 hours
  3. extractionExtract twice with dichloromethane
  4. dry with materialDry the separated organic layers over MgSO4
  5. filtrationfilter
  6. customevaporate in vacuo

Sources & evidence

ORD record
ord-784a2e5399874c028d725a65868b5745
Source dataset
uspto-grants-1997_11
Patent number
US05684017

Reaction notes

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