Sodium Hydroxide → HCID 21479355, compound

HRID 2292699Notes

Reaction equation

HRID 2292699 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH2:18][C:19]1[CH:24]=[C:23]3[O:25][CH2:26][O:27][C:22]3=[CH:21][C:20]=1[Cl:28])[C:13]([C:29]([O:31]CC)=[O:30])=[C:12]2[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:2]1C=CC=C[CH:3]=1.[Na].[OH-].[Na+]>C(O)C>[Cl:28][C:20]1[CH:21]=[C:22]2[O:27][CH2:26][O:25][C:23]2=[CH:24][C:19]=1[CH2:18][N:14]1[C:15]2[C:11](=[CH:10][C:9]([O:8][CH2:1][CH2:2][CH3:3])=[CH:17][CH:16]=2)[C:12]([C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)=[C:13]1[C:29]([OH:31])=[O:30]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 5360545SodiumHCID 21479360HCID 21479360, compound

Product 1

HCID 21479355HCID 21479355, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure of Example 1(d) except substituting ethyl 1-(2-chloro-4,5-methylenedioxybenzyl)-3-phenyl-5-propyloxyindole-2-carboxylate for ethyl 5-benzyloxy-1-(2-chloro-4,5-methylenedioxybenzyl)-3-phenylindole-2-carboxylate, the title compound was prepared as a white solid (0.053 g, 88%). The title compound was converted to the sodium salt using 1.0 eq of 0.1N sodium hydroxide in ethanol. MS (MH+): 464.0.

Sources & evidence

ORD record
ord-2afc506dae2f4f859cdf55cb1bb812e7
Source dataset
uspto-grants-1997_11
Patent number
US05684032

Reaction notes

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