Isopropanol → HCID 54083253, compound

HRID 2292702Notes

Reaction equation

[Cl:1][C:2]1[CH:29]=[C:28]2[O:30][CH2:31][O:32][C:27]2=[CH:26][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([OH:14])=[CH:11][CH:12]=2)[C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:6]1[C:21]([O:23]CC)=[O:22].[CH3:33][S:34][C:35]1[CH:42]=[CH:41][C:38]([CH2:39]O)=[CH:37][CH:36]=1.[CH:43](O)(C)C>>[Cl:1][C:2]1[CH:29]=[C:28]2[O:30][CH2:31][O:32][C:27]2=[CH:26][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH2:39][C:38]3[CH:41]=[CH:42][C:35]([S:34][CH3:33])=[CH:36][CH:37]=3)=[CH:11][CH:12]=2)[C:7]([C:15]2[CH:20]=[CH:19][C:18]([CH3:43])=[CH:17][CH:16]=2)=[C:6]1[C:21]([OH:23])=[O:22]

Participants

Reactant 3

HCID 3776Isopropanol

HCID 592968[4-(Methylsulfanyl)phenyl]methanol

HCID 21479382HCID 21479382, compound

Product 1

HCID 54083253HCID 54083253, compound

Procedure

Following the procedure of Example 18(a)-18(b), except substituting ethyl 1-(2-chloro-4,5-methylenedioxybenzyl)-5-hydroxy-3-(4-methylphenyl)indole-2-carboxylate for ethyl 1-(2-chloro-4,5-methylenedioxybenzyl)-5-hydroxy-3-phenylindole-2-carboxylate and 4-methylthiobenzyl alcohol for isopropanol in step (a), the title compound was prepared as a white solid (38% overall). MS (MH-): 570.0

Sources & evidence

ORD record: ord-b60ffe3f468e42bfa3aa0cec17a3c932
Source dataset: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05684032

Reaction notes

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