3-Methoxybenzyl chloride → HCID 21479361, compound

HRID 2292703Notes

Reaction equation

HRID 2292703 reaction equation
[Cl:1][C:2]1[CH:29]=[C:28]2[O:30][CH2:31][O:32][C:27]2=[CH:26][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([OH:14])=[CH:11][CH:12]=2)[C:7]([C:15]2[CH:20]=[C:19](Cl)[CH:18]=[C:17](Cl)[CH:16]=2)=[C:6]1[C:23]([O-:25])=[O:24].[CH3:33][O:34][C:35]1[CH:36]=[C:37]([CH:40]=[CH:41][CH:42]=1)[CH2:38]Cl.FC(F)(F)OC1C=CC(CBr)=CC=1>>[Cl:1][C:2]1[CH:29]=[C:28]2[O:30][CH2:31][O:32][C:27]2=[CH:26][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH2:38][C:37]3[CH:40]=[CH:41][CH:42]=[C:35]([O:34][CH3:33])[CH:36]=3)=[CH:11][CH:12]=2)[C:7]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[C:6]1[C:23]([OH:25])=[O:24]

Participants

4

Reactant 3

HCID 699943-Methoxybenzyl chlorideHCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 178524040HCID 178524040, compound

Product 1

HCID 21479361HCID 21479361, compound

Procedure

Following the procedure of Example 26(c)-26(d), except substituting ethyl 1-(2-chloro-4,5-methylenedioxybenzyl)-5-hydroxy-3-phenylindole-2-carboxylate for 1-(2-chloro-4,5-methylenedioxybenzyl)-3-(3,5-dichlorophenyl)-5-hydroxyindole-2-carboxylate and 3-methoxybenzyl chloride for 4-trifluoromethoxybenzyl bromide in step (c), the title compound was prepared as a white solid (64% overall). MS (MH+): 542.4

Sources & evidence

ORD record
ord-701ffeebb6744bbcb22ed17495d9a701
Source dataset
uspto-grants-1997_11
Patent number
US05684032

Reaction notes

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