Trichloroacetic Acid → O-[2-(4-Chlorophenoxy)propyl]hydroxylamine

Participants

Reaction Conditions

Reaction Steps

A mixture of 10 g (4.13 mmol) of acetone O-[2-(4-chlorophenoxy)-propyl]-oxime (compound 28 in Table 1) and 44 g of 30% strength by weight aqueous trichloroacetic acid solution was heated for 10 hours at 78° C. and a reduced pressure of 450 mbar in a stirred apparatus having an attached 30 cm column, 110 g of water being continuously added dropwise to the reaction mixture and the resulting water/acetone mixture being continuously distilled off. The reacted mixture was worked up by rendering it alkaline with 10% strength by weight sodium hydroxide solution and extracting it with toluene. 6 g of 2-(4-chlorophenoxy)-propoxyamine were isolated. Yield: 72%.

Provenance & Evidence