3-Methylisoquinoline → ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-3-METHYL-

HRID 2293132Notes

Reaction equation

HRID 2293132 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2>[Pt]=O.CO>[CH3:1][CH:2]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][NH:3]1

Participants

4

Reactant 1

HCID 143063-Methylisoquinoline

Product 1

HCID 568974ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-3-METHYL-Yield 107%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

3.0 g of 3-methylisoquinoline(21 mM) and 50 ml of methanol were mixed and 0.84 g of platinum oxide was added thereto. The mixture was subjected to hydrogenation at 40 psi and filtered. The filtrate was concentrated under a reduced pressure, to give 3.3 g of the title compound.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated under a reduced pressure

Sources & evidence

ORD record
ord-1e19945c3f7a45258bb9d02c007a1002
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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