O-Toluidine → HCID 21476439, compound

HRID 2293141Notes

Reaction equation

HRID 2293141 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:22][C:23]1[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=1[NH2:25]>CN(C)C=O>[ClH:1].[CH3:22][C:23]1[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=1[NH:25][C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 7242O-ToluidineHCID 226926412-Chloro-4-(3,4-dihydroisoquinolin-2(1H)-yl)quinazoline

Product 1

HCID 21476439HCID 21476439, compoundYield 22%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedures as in Example 18, except that to a mixture of 3.05 g of the compound (10.3 mM) prepared in Example 1 and 15 ml of dimethylform-amide, 2.2 ml of 2-methylaniline(20.6 mM) was added, 0.9 g of the title compound was prepared.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-bb2d3436bd2841dd94537829834c0cb1
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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