4-Fluoro-2-methylaniline → HCID 21476459, compound

HRID 2293142Notes

Reaction equation

HRID 2293142 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:22][C:23]1[CH:29]=[CH:28][C:26]([NH2:27])=[C:25]([CH3:30])[CH:24]=1>CN(C)C=O>[ClH:1].[F:22][C:23]1[CH:29]=[CH:28][C:26]([NH:27][C:2]2[N:11]=[C:10]([N:12]3[CH2:21][CH2:20][C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)=[C:25]([CH3:30])[CH:24]=1

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 226926412-Chloro-4-(3,4-dihydroisoquinolin-2(1H)-yl)quinazoline

Product 1

HCID 21476459HCID 21476459, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedures as in Example 18, except that to a mixture of 2.2 g of the compound(7 mM) prepared in Example 1 and 15 ml of dimethylformamide, 1.7 ml of 4-fluoro-2-methylaniline(15 mM) was added, 1.35 g of the title compound was prepared.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-81ad90943ea748b190ea1004a5751f75
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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