4-Fluoro-N-methylaniline → HCID 70198035, compound

HRID 2293149Notes

Reaction equation

HRID 2293149 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13]2)[C:9]2[C:4](=[C:5]([O:22][CH3:23])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:24][C:25]1[CH:32]=[CH:31][C:28]([NH:29][CH3:30])=[CH:27][CH:26]=1>CN(C)C=O>[ClH:1].[CH3:23][O:22][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[N:3]=[C:2]([N:29]([C:28]1[CH:31]=[CH:32][C:25]([F:24])=[CH:26][CH:27]=1)[CH3:30])[N:11]=[C:10]2[N:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13]1

Participants

4

Reactant 2

HCID 680244-Fluoro-N-methylanilineHCID 21476505HCID 21476505, compound

Product 1

HCID 70198035HCID 70198035, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedures as in Example 18, except that to a mixture of 2.0 g of the compound (6.14 mM) prepared in Example 4 and 15 ml of dimethyl-formamide, 1.5 g of 4-fluoro-N-methylaniline(12.2 mM) was added, 1.05 g of the title compound was prepared.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-bbda5fd6cbb44ad8a5afa0df978ed063
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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