4-Fluoro-2-methylaniline → HCID 22879026, compound

HRID 2293153Notes

Reaction equation

HRID 2293153 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C@@H:13]2[CH3:22])[C:9]2[C:4](=[C:5]([O:23][CH3:24])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:25][C:26]1[CH:32]=[CH:31][C:29]([NH2:30])=[C:28]([CH3:33])[CH:27]=1>CN(C)C=O>[ClH:1].[CH3:24][O:23][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[N:3]=[C:2]([NH:30][C:29]1[CH:31]=[CH:32][C:26]([F:25])=[CH:27][C:28]=1[CH3:33])[N:11]=[C:10]2[N:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C@@H:13]1[CH3:22]

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 53767120HCID 53767120, compound

Product 1

HCID 22879026HCID 22879026, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedures as in Example 18, except that to a mixture of 2.64 g of the compound (7.77 mM) prepared in Example 7 and 15 ml of dimethyl-formamide, 1.33 ml of 4-fluoro-2-methylaniline(16.3 mM) was added, 1.60 g of the title compound was prepared.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-d9d8766b18a04a04a1d6ca2e20a66b39
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

Loading…