4-Fluoro-N-methylaniline → HCID 21476509, compound

HRID 2293157Notes

Reaction equation

HRID 2293157 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]2[CH3:22])[C:9]2[C:4](=[C:5]([O:23][CH3:24])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:25][C:26]1[CH:33]=[CH:32][C:29]([NH:30][CH3:31])=[CH:28][CH:27]=1>CN(C)C=O>[ClH:1].[CH3:24][O:23][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[N:3]=[C:2]([N:30]([C:29]1[CH:32]=[CH:33][C:26]([F:25])=[CH:27][CH:28]=1)[CH3:31])[N:11]=[C:10]2[N:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]1[CH3:22]

Participants

4

Reactant 2

HCID 680244-Fluoro-N-methylanilineHCID 21476458HCID 21476458, compound

Product 1

HCID 21476509HCID 21476509, compoundYield 48.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedures as in Example 18, except that to a mixture of 1.00 g of the compound (2.94 mM) prepared in Example 5 and 15 ml of dimethyl-formamide, 0.77 g of 4-fluoro-N-methyl aniline(6.18 mM) was added, 0.66 g of the title compound was prepared.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-b69f44005551414bb81bf9666b6b6d5e
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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