4-Fluoro-2-methylaniline → HCID 21476422, compound

HRID 2293158Notes

Reaction equation

HRID 2293158 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]2[C:22]([F:25])([F:24])[F:23])[C:9]2[C:4](=[C:5]([O:26][CH3:27])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:28][C:29]1[CH:35]=[CH:34][C:32]([NH2:33])=[C:31]([CH3:36])[CH:30]=1>CN(C)C=O>[ClH:1].[F:28][C:29]1[CH:35]=[CH:34][C:32]([NH:33][C:2]2[N:11]=[C:10]([N:12]3[CH2:21][CH2:20][C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH:13]3[C:22]([F:23])([F:24])[F:25])[C:9]3[C:4](=[C:5]([O:26][CH3:27])[CH:6]=[CH:7][CH:8]=3)[N:3]=2)=[C:31]([CH3:36])[CH:30]=1

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 54041435HCID 54041435, compound

Product 1

HCID 21476422HCID 21476422, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedures as in Example 18, except that to a mixture of 1.9 g of the compound (4.82 mM) prepared in Example 8 and 15 ml of dimethyl-formamide, 0.82 ml of 4-fluoro-2-methyl aniline(10.1 mM) was added, 1.32 g of the title compound was prepared.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-353e1089c51b450eabf172c39f1137c2
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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