4-Fluoro-2-methylaniline → HCID 21476480, compound

HRID 2293162Notes

Reaction equation

HRID 2293162 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]2[CH2:22][CH3:23])[C:9]2[C:4](=[C:5]([O:24][CH3:25])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:26][C:27]1[CH:33]=[C:32]([F:34])[CH:31]=[CH:30][C:28]=1[NH2:29]>CN(C)C=O>[ClH:1].[CH3:25][O:24][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[N:3]=[C:2]([NH:29][C:28]1[CH:30]=[CH:31][C:32]([F:34])=[CH:33][C:27]=1[CH3:26])[N:11]=[C:10]2[N:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]1[CH2:22][CH3:23]

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 21476511HCID 21476511, compound

Product 1

HCID 21476480HCID 21476480, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedures as in Example 18, except that to a mixture of 1.5 g of the compound (4.63 mM) prepared in Example 10 and 15 ml of dimethyl-formamide, 0.80 ml of 2-methyl-4-fluoroaniline(9.73 mM) was added, 0.70 g of the title compound was prepared.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-6d5f09ce99664b8dab311a5f8a07c99c
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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