4-Fluoro-2-methylaniline → HCID 21476442, compound

HRID 2293163Notes

Reaction equation

HRID 2293163 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]2[CH:22]2[CH2:24][CH2:23]2)[C:9]2[C:4](=[C:5]([O:25][CH3:26])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:27][C:28]1[CH:34]=[CH:33][C:31]([NH2:32])=[C:30]([CH3:35])[CH:29]=1>CN(C)C=O>[ClH:1].[F:27][C:28]1[CH:34]=[CH:33][C:31]([NH:32][C:2]2[N:11]=[C:10]([N:12]3[CH2:21][CH2:20][C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH:13]3[CH:22]3[CH2:23][CH2:24]3)[C:9]3[C:4](=[C:5]([O:25][CH3:26])[CH:6]=[CH:7][CH:8]=3)[N:3]=2)=[C:30]([CH3:35])[CH:29]=1

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 54198961HCID 54198961, compound

Product 1

HCID 21476442HCID 21476442, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedures as in Example 18, except that to a mixture of 2.25 g of the compound (6.15 mM) prepared in Example 11 and 15 ml of dimethyl-formamide, 1.05 ml of 4-fluoro-2-methylaniline(12.9 mM) was added, 2.15 g of the title compound was prepared.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-6b64412226b949d69daafbd2f859669f
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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