4-Fluoroaniline → HCID 21476436, compound

HRID 2293166Notes

Reaction equation

HRID 2293166 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]2([CH3:23])[CH3:22])[C:9]2[C:4](=[C:5]([O:24][CH3:25])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:26][C:27]1[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=1>CN(C)C=O>[ClH:1].[F:26][C:27]1[CH:33]=[CH:32][C:30]([NH:31][C:2]2[N:11]=[C:10]([N:12]3[CH2:21][CH2:20][C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[C:13]3([CH3:23])[CH3:22])[C:9]3[C:4](=[C:5]([O:24][CH3:25])[CH:6]=[CH:7][CH:8]=3)[N:3]=2)=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 21476499HCID 21476499, compound

Product 1

HCID 21476436HCID 21476436, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedures as in Example 18, except that to a mixture of 1.80 g of the compound (5.0 mM) prepared in Example 13 and 10 ml of dimethyl-formamide, 1.10 ml of 4-fluoroaniline(11 mM) was added, 1.14 g of the title compound was prepared.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-4b05edff031245dba617c1618f3be9bd
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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