Diisopropylethylamine → HCID 57757711, compound

HRID 229323Notes

Reaction equation

HRID 229323 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[NH2:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[CH2:18][CH2:17][CH2:16]2.C(N(C(C)C)CC)(C)C>O1CCOCC1>[Cl:1][C:2]1[N:7]=[C:6]([NH:12][C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[CH2:18][CH2:17][CH2:16]3)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 90496Indan-5-amineHCID 5212662,4-Dichloro-5-nitropyrimidine

Product 1

HCID 57757711HCID 57757711, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
25 °C

Procedure

To 2,4-dichloro-5-nitropyrimidine (5.0 g, 25.8 mmol) in dioxane (35 mL) was added a solution of 5-aminoindane (3.43 g, 25.8 mmol) in dioxane (9 mL) and diisopropylethyl amine (4.5 mL, 25.8 mmol). The mixture was stirred at 25° C. for 1 hr and then concentrated to a residue to provide crude (2-chloro-5-nitro-pyrimidin-4-yl)-indan-5-yl-amine, (1).

Workup

  1. concentrationconcentrated to a residue

Sources & evidence

ORD record
ord-7f84dc27755e4b2288f5c57eac1bb502
Source dataset
uspto-grants-2009_07
Patent number
US07563781B2

Reaction notes

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