4-Cyanobenzaldehyde → HCID 69955017, compound

HRID 2293309Notes

Reaction equation

HRID 2293309 reaction equation
[C:1]([C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1)#[N:2].[NH:11]1[CH2:18][CH2:17][CH2:16][C@H:12]1C(O)=O.[CH2:19]([N:23]1[C:27](=[O:28])[CH:26]=[CH:25][C:24]1=[O:29])[CH2:20][CH2:21][CH3:22]>>[CH2:19]([N:23]1[C:27](=[O:28])[CH:26]2[CH:7]([C:6]3[CH:9]=[CH:10][C:3]([C:1]#[N:2])=[CH:4][CH:5]=3)[N:11]3[CH:12]([CH:25]2[C:24]1=[O:29])[CH2:16][CH2:17][CH2:18]3)[CH2:20][CH2:21][CH3:22]

Participants

4

Reactant 3

HCID 660424-CyanobenzaldehydeHCID 145742L-ProlineHCID 2397801-Butyl-1H-pyrrole-2,5-dione

Product 1

HCID 69955017HCID 69955017, compound

Procedure

7.B)c) (3aRS,4RS,8aSR,8bSR)-4-(2-Butyl-decahydro-1,3-dioxo-pyrrolo[3,4-a]pyrrolizin-4-yl)-benzonitrile was prepared analogously to Example 4.B)g) from 4-cyano-benzaldehyde, L-proline and N-butylmaleimide. Yellow oil. 1 H-NMR (DMSO-D6): 7.74 (d, ArH); 7.49 (d, ArH); 4.22 (d, 4-H).

Sources & evidence

ORD record
ord-9cc2189dedd84f9ca031baa11b2ee9f0
Source dataset
uspto-grants-1997_11
Patent number
US05686459

Reaction notes

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