反应详情

Using the procedure described in example 5, treatment of L-proline-L-isoleucine benzylamide (47 mg, 0.15 mmol), with sodium carbonate (31 mg, 0.29 mmol, 2.0 eq), and methyl alpha-bromoacetate (113 mg, 0.74 mmol, 5.0 eq) in acetonitrile (5 mL), provided 50 mg (87%) of L-isoleucine, N-[1-(2-methoxy-2-oxoethyl)-L-prolyl] benzylamide as a white foam.