Hydrochloric Acid → HCID 131720300, compound

HRID 2293419Notes

Reaction equation

HRID 2293419 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14](=[O:33])[CH2:15][CH:16]([NH:25][C:26](=[O:32])[C@@H:27]2[CH2:31][CH2:30][CH2:29][NH:28]2)[CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>CCOCC>[ClH:1].[CH3:13][O:12][C:8]1[CH:7]=[C:6]([C:14](=[O:33])[CH2:15][CH:16]([NH:25][C:26](=[O:32])[C@@H:27]2[CH2:31][CH2:30][CH2:29][NH:28]2)[CH2:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:5]=[C:4]([O:3][CH3:2])[C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131720301HCID 131720301, compound

Product 1

HCID 131720300HCID 131720300, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following the procedure described in Example 120, the coupling of N-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl]-L-proline hydrochloride (300 mg, 0.83 mmol) and 3-phenylpropylamine (0.36 mL, 2.5 mmol) provided, after treatment with HCl in Et2O, 120 mg of the hydrochloride salt of L-proline, 1-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl] 3-phenylpropylamide as a powder.

Sources & evidence

ORD record
ord-eaa581710d1146e7b4e7fa8dd98febab
Source dataset
uspto-grants-1997_11
Patent number
US05686424

Reaction notes

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