Hydrochloric Acid → HCID 131720302, compound

HRID 2293420Notes

Reaction equation

HRID 2293420 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14](=[O:34])[CH2:15][CH:16]([NH:26][C:27](=[O:33])[C@@H:28]2[CH2:32][CH2:31][CH2:30][NH:29]2)[CH2:17][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>CCOCC>[ClH:1].[CH3:13][O:12][C:8]1[CH:7]=[C:6]([C:14](=[O:34])[CH2:15][CH:16]([NH:26][C:27](=[O:33])[C@@H:28]2[CH2:32][CH2:31][CH2:30][NH:29]2)[CH2:17][CH2:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:5]=[C:4]([O:3][CH3:2])[C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131720303HCID 131720303, compound

Product 1

HCID 131720302HCID 131720302, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following the procedure described in Example 120, the coupling of N-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl]-L-proline hydrochloride (300 mg, 0.83 mmol) and 4-phenylbutylamine (0.39 mL, 2.5 mmol) provided, after treatment with HCl in Et2O, 170 mg of the hydrochloride salt of L-proline, 1-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl] 4-phenylbutylamide as a powder.

Sources & evidence

ORD record
ord-b8e55ed190384241af257b58fc549e77
Source dataset
uspto-grants-1997_11
Patent number
US05686424

Reaction notes

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