Hydrochloric Acid → HCID 131720306, compound

HRID 2293422Notes

Reaction equation

HRID 2293422 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14](=[O:33])[CH2:15][C:16]2([CH:32]=[CH:31][CH:30]=[CH:29][CH2:28]2)[CH2:17][CH2:18][N:19]([CH3:27])[C:20](=[O:26])[C@@H:21]2[CH2:25][CH2:24][CH2:23][NH:22]2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>CCOCC>[ClH:1].[CH3:13][O:12][C:8]1[CH:7]=[C:6]([C:14](=[O:33])[CH2:15][C:16]2([CH:28]=[CH:29][CH:30]=[CH:31][CH2:32]2)[CH2:17][CH2:18][N:19]([CH3:27])[C:20](=[O:26])[C@@H:21]2[CH2:25][CH2:24][CH2:23][NH:22]2)[CH:5]=[C:4]([O:3][CH3:2])[C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131720307HCID 131720307, compound

Product 1

HCID 131720306HCID 131720306, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following the procedure described in Example 120, the coupling of N-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl]-L-proline hydrochloride (250 mg, 0.69 mmol) and N-methyl phenethylamine (0.30 mL, 2.1 mmol) provided, after treatment with HCl in Et2O, 20 mg of the hydrochloride salt of L-proline, 1-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl] N-methyl phenethylamide as a powder

Sources & evidence

ORD record
ord-93bfa03fcfdf497cb3feda2a96d12380
Source dataset
uspto-grants-1997_11
Patent number
US05686424

Reaction notes

Loading…