Hydrochloric Acid → HCID 131720310, compound

HRID 2293425Notes

Reaction equation

HRID 2293425 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14](=[O:37])[CH2:15][C:16]([NH:29][C:30](=[O:36])[C@@H:31]2[CH2:35][CH2:34][CH2:33][NH:32]2)([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>CCOCC>[ClH:1].[CH3:13][O:12][C:8]1[CH:7]=[C:6]([C:14](=[O:37])[CH2:15][C:16]([NH:29][C:30](=[O:36])[C@@H:31]2[CH2:35][CH2:34][CH2:33][NH:32]2)([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:5]=[C:4]([O:3][CH3:2])[C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131720311HCID 131720311, compound

Product 1

HCID 131720310HCID 131720310, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following the procedure described in Example 120, the coupling of N-[2-(3,4,5-trimethoxyphenyl)-2 -oxoethyl]-L-proline hydrochloride (250 mg, 0.69 mmol) and aminodiphenylmethane (0.12 mL, 0.69 mmol) provided, after treatment with HCl in Et2O, 132 mg of the hydrochloride salt of L-proline, 1-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl] diphenylmethylamide as a powder.

Sources & evidence

ORD record
ord-ad6cb58d33aa47349e50889c906acf6d
Source dataset
uspto-grants-1997_11
Patent number
US05686424

Reaction notes

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