Hydrochloric Acid → HCID 67620159, compound

HRID 2293426Notes

Reaction equation

HRID 2293426 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14](=[O:38])[CH2:15][C:16]([NH:30][C:31](=[O:37])[C@@H:32]2[CH2:36][CH2:35][CH2:34][NH:33]2)([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>CCOCC>[ClH:1].[CH3:13][O:12][C:8]1[CH:7]=[C:6]([C:14](=[O:38])[CH2:15][C:16]([NH:30][C:31](=[O:37])[C@@H:32]2[CH2:36][CH2:35][CH2:34][NH:33]2)([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:5]=[C:4]([O:3][CH3:2])[C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67620160HCID 67620160, compound

Product 1

HCID 67620159HCID 67620159, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following the procedure described in Example 120, the coupling of N-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl]-L-proline hydrochloride (250 mg, 0.69 mmol) and 1,2-diphenylethylamine (0.40 mL, 2.1 mmol) provided, after treatment with HCl in Et2O, 95 mg of the hydrochloride salt of L-proline, 1-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl] 1,2-diphenylethylamide as a powder.

Sources & evidence

ORD record
ord-a22f64ae65e44b50963a6725671165ec
Source dataset
uspto-grants-1997_11
Patent number
US05686424

Reaction notes

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