2-Propylvaleryl chloride → HCID 22879053, compound

HRID 2293451Notes

Reaction equation

HRID 2293451 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:25])[C@@H:13]2[CH2:17][CH2:16][CH2:15][N:14]2[CH2:18][C@@H:19]([NH2:24])[CH2:20][CH:21]([CH3:23])[CH3:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:26]([CH:29]([CH2:33][CH2:34][CH3:35])[C:30](Cl)=[O:31])[CH2:27][CH3:28]>>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:25])[C@@H:13]2[CH2:17][CH2:16][CH2:15][N:14]2[CH2:18][C@@H:19]([NH:24][C:30](=[O:31])[CH:29]([CH2:33][CH2:34][CH3:35])[CH2:26][CH2:27][CH3:28])[CH2:20][CH:21]([CH3:22])[CH3:23])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 762402-Propylvaleryl chlorideHCID 22873003HCID 22873003, compound

Product 1

HCID 22879053HCID 22879053, compoundYield 60%

Procedure

Using the procedure described in Example 7, treatment of 1-[2-(S)-amino-4-methylpentyl]-L-proline 4-phenylbutylamide (20 mg) with di-n-propylacetyl chloride(14 uL) provided 16 mg (60%) of the title compound. The 1H NMR and Mass spectrum analysis of this compound was consistent with the structure.

Sources & evidence

ORD record
ord-60e2d3c6c8804f27825e6ed0ad28ec78
Source dataset
uspto-grants-1997_11
Patent number
US05686469

Reaction notes

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