9-Fluorenone-4-carbonyl chloride → HCID 22879061, compound

HRID 2293456Notes

Reaction equation

HRID 2293456 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:25])[C@@H:13]2[CH2:17][CH2:16][CH2:15][N:14]2[CH2:18][C@@H:19]([NH2:24])[CH2:20][CH:21]([CH3:23])[CH3:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:26]1[C:38]2[C:37](=[O:39])[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[C:30]=2[C:29]([C:40](Cl)=[O:41])=[CH:28][CH:27]=1>>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:25])[C@@H:13]2[CH2:17][CH2:16][CH2:15][N:14]2[CH2:18][C@@H:19]([NH:24][C:40]([C:29]2[C:30]3[C:31]4[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=4)[C:37](=[O:39])[C:38]=3[CH:26]=[CH:27][CH:28]=2)=[O:41])[CH2:20][CH:21]([CH3:22])[CH3:23])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 6101429-Fluorenone-4-carbonyl chlorideHCID 22873003HCID 22873003, compound

Product 1

HCID 22879061HCID 22879061, compoundYield 18%

Procedure

Using the procedure described in Example 7, treatment of 1-[2-(S)-amino-4-methylpentyl ]-L-proline 4-phenylbutylamide (134 mg) with 9-fluorenone-4-carbonyl chloride (131 mg) provided 35 mg(18%) of the title compound. The 1H NMR and Mass spectrum analysis of this compound was consistent with the structure.

Sources & evidence

ORD record
ord-35c894c60b4842a78375af59806588d1
Source dataset
uspto-grants-1997_11
Patent number
US05686469

Reaction notes

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