HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → (R)-5-Ethynyl-N-{2-methoxy-1-[3-methyl-4-(3-oxomorpholin-4-yl)phenylcarbamoyl]ethyl}thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 5-Ethynylthiophene-2-carboxylic acid | HCID 45084750 | — |
| Reactant | 2-(R)-amino-3-methoxy-N-[3-methyl-4-(3-oxomorpholin-4-yl)phenyl]propionamide | HCID 68872428 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (R)-5-Ethynyl-N-{2-methoxy-1-[3-methyl-4-(3-oxomorpholin-4-yl)phenylcarbamoyl]ethyl}thiophene-2-carboxamide | HCID 11611953 | — |
Reaction Steps
Prepared analogously to Example 1a from 5-ethynylthiophene-2-carboxylic acid and 2-(R)-amino-3-methoxy-N-[3-methyl-4-(3-oxomorpholin-4-yl)phenyl]propionamide with TBTU and NMM in DMF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563786B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-c8915e73a530494a9e024e16ccc687bf |
| Source note | uspto-grants-2009_07 |