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HRID229347

反应详情

EQUATION

反应方程式

HRID 229347 的结构方程式

REACTANTS

反应物

4
结构：CN1CCOCC1
HCID7972

4-Methylmorpholine

C5H11NO

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：C#Cc1ccc(C(=O)O)s1
HCID45084750

5-Ethynylthiophene-2-carboxylic acid

C7H4O2S

结构：COC[C@@H](N)C(=O)Nc1ccc(N2CCOCC2=O)c(C)c1
HCID68872428

未命名化合物

PRODUCTS

生成物

1
结构：C#Cc1ccc(C(=O)N[C@H](COC)C(=O)Nc2ccc(N3CCOCC3=O)c(C)c2)s1
HCID11611953

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared analogously to Example 1a from 5-ethynylthiophene-2-carboxylic acid and 2-(R)-amino-3-methoxy-N-[3-methyl-4-(3-oxomorpholin-4-yl)phenyl]propionamide with TBTU and NMM in DMF.