Hydrogen Peroxide → 4-Methylsulfinyl-2-methoxy-5-nitrobenzoic acid

HRID 2293531Notes

Reaction equation

HRID 2293531 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12][CH3:13])[C:9]([N+:14]([O-:16])=[O:15])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[OH:17]O>C(O)(=O)C>[CH3:13][S:12]([C:10]1[C:9]([N+:14]([O-:16])=[O:15])=[CH:8][C:4]([C:5]([OH:7])=[O:6])=[C:3]([O:2][CH3:1])[CH:11]=1)=[O:17]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 214770482-Methoxy-4-methylthio-5-nitrobenzoic acid

Product 1

HCID 214769844-Methylsulfinyl-2-methoxy-5-nitrobenzoic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A 0.50 g portion of 2-methoxy-4-methylthio-5-nitrobenzoic acid was suspended in 5 ml of acetic acid, and 0.77 ml of 30% hydrogen peroxide aqueous solution was added thereto, followed by 12 hours of stirring. After completion of the reaction, the reaction solution was poured on crushed ice, and the thus precipitated product of interest was collected by filtration, washed with water and then dried under a reduced pressure to give 0.35 g of 4-methylsulfinyl-2-methoxy-5-nitrobenzoic acid.

Workup

  1. customAfter completion of the reaction
  2. additionthe reaction solution was poured
  3. customon crushed ice
  4. filtrationthe thus precipitated product of interest was collected by filtration
  5. washwashed with water
  6. customdried under a reduced pressure

Sources & evidence

ORD record
ord-5997127b2c5a4750aeaa4dd80eb61bec
Source dataset
uspto-grants-1997_11
Patent number
US05686482

Reaction notes

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