反应详情

温度

50 °C

A 1.96 g portion of acetic anhydride was mixed with 0.89 ml of formic acid, followed by stirring at 50° C. for 2 hours. The resulting solution was mixed with 1.5 g of methyl 5-amino-2,4-dimethoxybenzoate dissolved in advance in 3 ml of tetrahydrofuran, followed by 6 hours stirring. After completion of the reaction, the thus precipitated product of interest was collected by filtration, washed with diethyl ether and then dried under a reduced pressure to give 1.62 g of methyl 2,4-dimethoxy-5-formylaminobenzoate.

1. waitfollowed by 6 hours
2. stirringstirring
3. customAfter completion of the reaction
4. filtrationthe thus precipitated product of interest was collected by filtration
5. washwashed with diethyl ether
6. customdried under a reduced pressure