Acetic Acid → HCID 54218971, compound

HRID 2293600Notes

Reaction equation

HRID 2293600 reaction equation
[F:1][C:2]([F:38])([CH2:34][CH2:35][CH2:36][CH3:37])[C:3](=[O:33])[CH2:4][CH2:5][C@H:6]1[C@H:10]([O:11]C2CCCCO2)[CH2:9][C:8](=[O:18])[C@@H:7]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([O:29][CH:30]([CH3:32])[CH3:31])=[O:28].C(O)(=O)C.O>C1COCC1>[F:1][C:2]([F:38])([CH2:34][CH2:35][CH2:36][CH3:37])[C:3](=[O:33])[CH2:4][CH2:5][C@H:6]1[C@H:10]([OH:11])[CH2:9][C:8](=[O:18])[C@@H:7]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([O:29][CH:30]([CH3:31])[CH3:32])=[O:28]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 962WaterHCID 54274056HCID 54274056, compound

Product 1

HCID 54218971HCID 54218971, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The compound (59) (0.288 g) was dissolved in a mixed solvent (30 ml) consisting of acetic acid, water and THF (4:2:1) and the solution was kept at 45° C. for 3.5 hours. The resultant mixture was worked up with the conventional procedure and the obtained crude product was subjected to silicagel column chromatography to give the titled compound (60). Yield: 0.184 g (76%).

Workup

  1. customthe obtained crude product

Sources & evidence

ORD record
ord-a3330018880f4804abc81fd2b16fc051
Source dataset
uspto-grants-1997_11
Patent number
US05686487

Reaction notes

Loading…