HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(4-Fluorophenyl)quinazolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | 2-Amino-4'-fluorobenzophenone | HCID 9837287 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-(4-Fluorophenyl)quinazolin-2(1H)-one | HCID 22101691 | — |
Reaction Steps
4'-Fluoro-2-aminobenzophenone (164.5 g, 1.20 mol) is heated with urea (72.09 g, 0.500 mol) at 195° C. (1 h) in NMP (500 mL). The solution is cooled and poured into water (2 L). The product is collected by filtration and dried. The product is purified by recrystallization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05686560 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-71d0ea32cfc249b5989d4d9cd4af68e5 |
| Source note | uspto-grants-1997_11 |